Metformin Induced Lactic Acidosis
นอกจากการดูบทความนี้แล้ว คุณยังสามารถดูข้อมูลที่เป็นประโยชน์อื่นๆ อีกมากมายที่เราให้ไว้ที่นี่: ดูเพิ่มเติม
Metformin USMLE Mnemonic
Metformin is the first line therapeutic drug used for Type 2 Diabetes. A drug in the biguanide class, metformin controls blood sugar in several ways. These include decreasing hepatic gluconeogenesis, increasing glycolysis, and increasing peripheral glucose uptake and insulin sensitivity. Notably, metformin can increase production of lactate in the body, leading to lactic acidosis. This is particularly common in patients with impaired kidney function, which is why metformin is contraindicated in renal failure. Other side effects to note are GI upset and vitamin B12 deficiency
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usmle step1 diabetes mnemonic bloodsugar
Metformin: Mechanism of action. Pathogenesis of Lactic acidosis.
0:08 Inhibition of complex 1 in ETC
0:50 Activation of AMPK
3:22 AMPK mediated inhibition of Gluconeogenesis
3:44 Inhibition of Mitochondrial glycerophosphate dehydrogenase
5:36 NADH induced convertion of Pyruvate into Lactate
7:44 How Renal dysfunction affects Lactic acidosis
High yield for Step 1. Step 2
Mechanism of inhibition of Mitochondrial glycerophosphate dehydrogenase (mGPDH). Activation of AMPactivated protein kinase (AMPK kinase).
CƠ CHẾ TÁC DỤNG NHÓM BIGUANID (METFORMIN)
Cơ chế tác dụng thuốc trị đái tháo đường tuyp 2 biguanid/thuốc chỉ định đầu bảng trị ĐTĐ tuýp 2
Lactic Acidosis: What is it, Causes (ex. metformin), and Subtypes A vs B
Lactic Acidosis: Biological pathway, causes, and subtypes. Elevated lactate production can lead to lactic acidosis which can be a serious condition and is the most common cause of metabolic acidosis in hospitalized patients. There are a variety of causes of lactic acid production including increased pyruvate production, decreased pyruvate utilization, and decreased removal of lactic acid production. In this lesson, you will learn the definition of hyperlactatemia and lactic acidosis, along with a pathophysiological breakdown of the how it occurs, and you will also learn about a variety of causes of lactic acidosis. You will also learn the differences between Type A Lactic Acidosis and Type B Lactic Acidosis.
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